Venom Supplies peptide toxins merge venom-derived diversity with synthetic reproducibility. Our catalog aggregates lyophilized peptides generated through solid-phase peptide synthesis (SPPS), recombinant expression, and purified native fractions. Each lot is authenticated via LC-MS and amino acid analysis, ensuring precise molecular weights and disulfide connectivity. We standardize vial fill masses and deliver technical notes on reconstitution buffers compatible with electrophysiology and imaging assays.
Channel subtype selectivity at research scale
Peptide toxins remain unrivaled for dissecting channel subtype function due to their high affinity and state dependence. Venom Supplies catalog highlights include NaV1.7 inhibitors modeled on μ-conotoxins, Kv1.3 blockers adapted from scorpion peptides, and α-bungarotoxin variants for nicotinic acetylcholine receptor targeting. Each listing indicates kinetic parameters (kon/koff), recommended working concentrations, and counter-screening results, supporting rational experimental design aligned with the Ion Channel Research strategy.
Recombinant and synthetic customization
Investigators can request isotopically labeled or fluorescently tagged toxin variants for imaging or binding studies. Our peptide chemistry team supports point mutations to probe structure–activity relationships, guided by NMR structural models and molecular dynamics simulations. These customization options are outlined alongside standard catalog offerings to streamline the path from concept to validated assay reagents.
Documentation and compliance
Quality packs include HPLC chromatograms, mass spectra, and residual trifluoroacetic acid (TFA) quantitation. Stable storage guidance covers both short-term refrigerated use and long-term −20 °C or −80 °C retention. Safety sheets summarize neurotoxic potency and recommend containment procedures consistent with GLP standards. Investigators can coordinate global shipments through the Ordering & Shipping portal, where temperature-controlled logistics are detailed.
Explore next steps
- Representative products: PTX-PPT-002 μ-conotoxin analog, PTX-PPT-005 Kv1.3-selective peptide, and PTX-PPT-009 α-bungarotoxin derivative.
- Complementary resources include Choosing the right toxin for sodium channel subtypes and the Receptor Pharmacology deep dive.
- For translational collaborations or custom conjugation, engage our senior peptide chemists via the Contact page.
Venom Supplies peptide toxins provide the precision, purity, and documentation required by advanced electrophysiology, structural biology, and drug discovery teams.