Venom Supplies organizes venom-derived and synthetic toxins by their primary molecular targets to streamline assay selection and facilitate translational research. The Toxins by Target collection provides curated subcategories for voltage-gated sodium (NaV), potassium (Kv), and calcium (CaV) channels, nicotinic acetylcholine receptors (nAChRs), transient receptor potential (TRP) channels, and emerging targets such as acid-sensing ion channels (ASICs) and PIEZO mechanosensors.
Guided target families
- Sodium channel toxins: Explore μ-conotoxins, β-scorpion toxins, and spider peptides with defined selectivity across NaV1.3, NaV1.7, NaV1.8, and cardiac NaV1.5. Each listing details state dependence, on/off kinetics, and recommended holding potentials for voltage-clamp assays.
- Potassium channel toxins: Access scorpion-derived Kv blockers (margatoxin analogs), dendrotoxins affecting Kv1 subfamilies, and sea anemone peptides with preferential Kv3.4 activity. Useful for immunology, neurophysiology, and cardiac repolarization studies.
- Calcium channel toxins: Survey ω-conotoxins and agatoxins targeting CaV2.x and P/Q-type channels, complete with synaptic release inhibition data.
- Nicotinic receptor antagonists: Select α-bungarotoxin variants and kappa-bungarotoxin analogs for neuromuscular junction and α7 receptor investigations.
- TRP and mechanosensitive modulators: Identify spider and scorpion peptides modulating TRPV1, TRPA1, TRPM8, PIEZO1, and PIEZO2, supporting itch, pain, and mechanotransduction programs.
Integration with experimental workflows
The target-driven taxonomy mirrors the needs of electrophysiology and screening teams. Researchers can jump from target-family pages to associated Application guides, such as Ion Channel Research and Pain Research, and navigate directly to Product listings featuring relevant toxins. Internal links between products and applications reinforce topical authority for search queries like “sodium channel toxins for pain research” or “purchase Kv1.3 blockers for immunology.”
Quality and support
All entries include COA references, stability profiles, and SDS documents accessed via secure download after account validation. Venom Supplies data scientists continuously enrich target annotations with literature references, binding affinities, and structure–activity relationship insights, ensuring that catalog users access the most current information. Custom target mapping reports are available on request through the Support desk, assisting teams preparing regulatory dossiers or grant proposals.
Utilize the Toxins by Target collection to align each experiment with the most appropriate venom-derived or engineered modulator, reducing screening cycles and increasing confidence in downstream translational decisions.