Venom of Bufo gargarizans
| Product ID | PTX-AMV-L3107 |
|---|---|
| Name | Bufo gargarizans |
| Common Name(s) | asiatic toad, cinobufagin, bufalin, chan su |
| Origin | Captive-bred (Asia). |
| Purity | Whole Secretion |
| Form | Lyophilized powder |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price ($) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | 140.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Product Description
The venom of Bufo gargarizans, commonly known as the Asiatic Toad, is a complex chemical cocktail secreted from the parotoid glands and skin. This secretion, historically known as Chan Su in Traditional Chinese Medicine (TCM), has been utilized for centuries for its potent therapeutic properties. Modern pharmacological research has identified it as a rich source of bufadienolides, a class of cardiotonic steroids that exhibit significant biological activity.
Key bioactive components include:
- Cinobufagin: A potent cardiotonic steroid that has demonstrated strong anti-tumor efficacy in various cancer cell lines.
- Bufalin: Known for its ability to induce apoptosis (programmed cell death) in leukemia and solid tumor cells, while also inhibiting cell proliferation.
- Resibufogenin: Another major constituent with cardiotonic and anti-inflammatory properties.
Our Bufo gargarizans venom is collected from captive-bred specimens to ensure sustainability and consistency. The secretion is lyophilized (freeze-dried) to preserve the structural integrity of the bioactive peptides and steroids.
Research Applications
-
Oncology & Cancer Research:
- Investigation of bufadienolide-induced apoptosis pathways in human cancer cells (e.g., lung, liver, and prostate cancer).
- Study of the synergistic effects of toad venom components with conventional chemotherapy agents.
- Development of novel anti-cancer therapeutics targeting specific tumor markers.
-
Cardiovascular Pharmacology:
- Study of Na+/K+-ATPase inhibition, similar to the mechanism of digitalis, for potential applications in heart failure treatment.
- Analysis of the positive inotropic effects of bufadienolides on cardiac muscle.
-
Immunology & Inflammation:
- Evaluation of the anti-inflammatory and analgesic properties of the crude venom and its isolated fractions.
- Research into the modulation of immune responses by toad venom peptides.
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Traditional Medicine Validation:
- Scientific validation of the pharmacological basis for the use of Chan Su in treating infections, pain, and swelling.
Bufo gargarizans