Venom of Centruroides sculpturatus
| Product ID | PTX-SCV-006 |
|---|---|
| Name | Centruroides sculpturatus |
| Common Name(s) | kv peptide panel, scorpion toxin library, ion channel screening, centruroides sculpturatus venom |
| Origin | Controlled desert-habitat colony with standardized diet |
| Purity | >= 90% per peptide |
| Form | Five-peptide kit, 50 μg per peptide |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price ($) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | 750.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
The Centruroides Kv Peptide Panel consolidates five characterized peptides isolated from Centruroides sculpturatus venom, each purified via preparative HPLC and validated by tandem mass spectrometry. Peptides are provided in individual low-binding vials and annotated with amino acid sequences and disulfide connectivity.
Molecular targets
The panel includes:
- CsTx-1: Kv1.2-preferential blocker (IC₅₀ 12 nM) with minimal activity on Kv1.5.
- CsTx-2: Kv1.3 and Kv1.5 dual modulator enabling comparative pharmacology.
- CsTx-3: Kv1.1-selective binder for neuronal excitability studies.
- CsTx-4: Kv1.6 affinity reference for cerebellar circuits.
- CsTx-5: Kv1.x broad-spectrum toxin for assay calibration.
Potency tables and kinetic traces accompany the COA, supporting direct integration into high-throughput electrophysiology platforms.
Research applications
- Ion channel subtype screening: Rapidly profile medicinal chemistry series across Kv subfamilies.
- High-throughput electrophysiology: Utilize defined peptide standards to QC automated patch-clamp devices.
- Drug lead benchmarking: Compare candidate blockers against native peptide potency and selectivity.
Crosslinks: Scorpion Venoms, Ion Channel Research, and Choosing the right toxin for sodium channel subtypes for selection framework parallels.
Format & handling
Each peptide vial contains 50 μg lyophilized powder. Reconstitute in 0.1% trifluoroacetic acid (TFA) water or 20 mM HEPES, 150 mM NaCl, pH 7.4 with 0.1% BSA. Maintain on ice during preparation and aliquot to prevent adsorption.
Documentation
- COA: peptide purity, mass spectra, potency tables, endotoxin (< 0.05 EU/μg).
- SDS: toxicity overview, emergency measures, and waste handling instructions.
Safety notes
Observe BSL-2 containment. Avoid contact with skin or mucosa. Neutralize residues with oxidizing agents before disposal.
Related resources
- Complementary product: PTX-PPT-005 Kv1.3-Selective Peptide
- Application synergy: Receptor Pharmacology
- Technical assistance: Support
Centruroides sculpturatus