Venom of Crotalus durissus terrificus
| Product ID | PTX-SNV-001 |
|---|---|
| Name | Crotalus durissus terrificus |
| Common Name(s) | snake venom neurotoxin, crotalus durissus terrificus venom, sodium channel neurotoxin, nAchR antagonist |
| Origin | Lyophilized venom pooled from veterinary-monitored captive colony |
| Purity | >= 95% protein recovery |
| Form | Lyophilized powder, 500 μg per vial |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price (€) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | €550.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
Venom Supplies standardizes Crotalus durissus terrificus venom through sequential ultrafiltration and size-exclusion chromatography to enrich the crotoxin neurotoxin complex (phospholipase A2 plus crotapotin). Each lot is pooled from a veterinary-supervised colony, minimizing seasonal variability. LC-MS fingerprints confirm intact mass of the heterodimeric complex and quantify acidic/basic isoforms.
Molecular targets
Crotoxin components exhibit dual pharmacology: PLA2-mediated membrane disruption and presynaptic blockade of acetylcholine release. Voltage-clamp assays reveal sub-micromolar potency against NaV1.4 and NaV1.6, while displacement studies demonstrate high-affinity binding to muscle-type nicotinic receptors. Supplemental data summarize the complex’s modulatory effects on quantal release to inform neuromuscular blocking agent research.
Research applications
This preparation supports:
- Neuromuscular transmission assays requiring reproducible paralysis induction.
- State-dependent NaV characterization in skeletal muscle models.
- Antivenom neutralization panels benchmarking antibody potency.
Internal crosslinks: navigate to the Snake Venoms category for complementary fractions and review the Ion Channel Research application page for broader channel-selectivity context.
Format & handling
Reconstitute each 500 μg vial with 500 μL sterile PBS or physiological saline to yield 1 mg/mL stock. For extended studies, aliquot and store at −80 °C to preserve enzymatic activity. Avoid repeated freeze–thaw cycles.
Documentation
- COA: chromatographic profiles, protein concentration, endotoxin < 0.5 EU/mg.
- SDS: GHS classification, exposure controls, and neutralization guidelines.
Safety notes
Employ BSL-2 engineering controls. Decontaminate surfaces with 10% bleach followed by 70% ethanol. Dispose of sharps and consumables as regulated biohazard waste.
Related resources
- Product complement: PTX-SNV-004 Bothrops Metalloproteinase Fraction
- Application insight: Pain Research
- Reference reading: Best practices for handling and storing neurotoxins in the lab
Crotalus durissus terrificus
This reagent is part of our authenticated Snake Venoms collection.
Browse all Snake Venoms →Related Snake Venoms Reagents
Explore additional authenticated venom pools and fractions from the same taxonomic group.
Acanthophis antarcticus Venom
PTX-SNV-L1358Lyophilized venom from the Common Death Adder (Acanthophis antarcticus). Rich in post-synaptic neurotoxins (acanthopins) and anticoagulants.
Acanthophis praelongus Venom
PTX-SNV-L1359Venom from the Northern Death Adder (Acanthophis praelongus). Contains post-synaptic neurotoxins and anticoagulants.
Agkistrodon acutus Venom
PTX-SNV-L1245Venom from the Sharp-nosed Viper (Deinagkistrodon acutus). Contains potent hemotoxins, acutin (thrombin-like enzyme), and hemorrhagic metalloproteinases.