Venom of Leiurus quinquestriatus
| Product ID | PTX-SCV-003 |
|---|---|
| Name | Leiurus quinquestriatus |
| Common Name(s) | scorpion kv toxin, margatoxin analog, kv1.3 blocker, immunology toxin |
| Origin | Captive-bred colony with controlled photoperiod, North African lineage |
| Purity | >= 92% peptide content |
| Form | Lyophilized peptide concentrate, 100 μg per vial |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price (€) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | €600.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
Venom Supplies isolates Kv-active peptides from Leiurus quinquestriatus venom via reversed-phase HPLC, focusing on α-KTx family members. Peptides are desalted and lyophilized under inert atmosphere. LC-MS/MS sequencing confirms cystine knot motifs and identifies primary isoforms with masses ranging 3.8–4.2 kDa.
Molecular targets
Electrophysiology assays demonstrate nanomolar inhibition of Kv1.3, with partial cross-reactivity to Kv1.1 and Kv1.6. Potency values (IC₅₀ 15 ± 3 nM on human Kv1.3) and state-dependence charts accompany each shipment. Binding kinetics are derived from whole-cell patch clamp on Jurkat T cells and CHO expression systems.
Research applications
- Autoimmune disease modeling: Block Kv1.3 to suppress effector memory T cell activation.
- Effector memory T cell modulation: Evaluate cytokine shifts and Ca²⁺ signaling pathways.
- Patch-clamp validation: Benchmark instrument performance using consistent peptide standards.
Internal references: Scorpion Venoms category, Neuroscience application page, and blog insight How venom-derived toxins advance ion channel research.
Format & handling
Reconstitute 100 μg with 100 μL sterile PBS containing 0.1% BSA to minimize adsorption. Vortex gently and centrifuge briefly to collect solution at the bottom of the vial.
Documentation
- COA: peptide purity by HPLC, mass spectrometry confirmation, endotoxin (< 0.1 EU/μg).
- SDS: hazard statements, PPE requirements, first-aid measures.
Safety notes
Work in a certified biosafety cabinet. Employ double gloving and avoid generating aerosols. Dispose of waste via peptide degradation with sodium hypochlorite.
Related resources
- Complementary product: PTX-PPT-005 Kv1.3-Selective Peptide
- Application tie-in: Receptor Pharmacology
- Operational guidance: Support
Leiurus quinquestriatus
This reagent is part of our authenticated Scorpion Venoms collection.
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