Venom of Synthetic analog of Conus geographus peptide
| Product ID | PTX-PPT-002 |
|---|---|
| Name | Synthetic analog of Conus geographus peptide |
| Common Name(s) | mu conotoxin analog, nav1.7 inhibitor, synthetic peptide toxin, pain research toxin |
| Origin | Solid-phase peptide synthesis with orthogonal cysteine protection |
| Purity | >= 97% by HPLC |
| Form | Lyophilized peptide, 50 μg per vial |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price ($) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | 800.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
This synthetic μ-conotoxin analog incorporates stabilizing substitutions (Cys-to-Pen) to maintain disulfide architecture while increasing oxidative resilience. Solid-phase peptide synthesis (Fmoc) with orthogonal cysteine protection yields controlled folding, followed by RP-HPLC purification. LC-MS verifies expected mass (2635.9 Da) and disulfide alignment.
Molecular targets
Selective inhibition of NaV1.7 (IC₅₀ 3.8 nM) with moderate activity on NaV1.4 (IC₅₀ 42 nM) and negligible effect on NaV1.5. The peptide slows recovery from inactivation, reducing repetitive firing in dorsal root ganglion neurons. COA includes voltage-dependence plots and protocol notes for step depolarization assays.
Research applications
- Pain pathway research: Evaluate NaV1.7 contribution to nociceptive firing.
- Voltage clamp validation: Provide a reproducible reference for manual or automated patch clamp.
- Structure-activity studies: Compare analog potency to native μ-conotoxin sequences.
Refer to the Peptide Toxins category, Pain Research, and blog article Choosing the right toxin for sodium channel subtypes.
Format & handling
Reconstitute with 50 μL sterile 20 mM HEPES, 150 mM NaCl, pH 7.4 with 0.05% Tween-20. Aliquot into low-binding tubes and freeze at −80 °C.
Documentation
- COA: HPLC purity, mass spectrum, activity curves, endotoxin (< 0.05 EU/μg).
- SDS: hazard communications, PPE, spill handling.
Safety notes
Work in a BSL-2 cabinet. Remove residues with 0.5% sodium hypochlorite followed by water rinse.
Related resources
- Complementary product: PTX-MTX-001 ω-Conotoxin CVIF
- Application synergy: Ion Channel Research
- Support contact: Support
Synthetic analog of Conus geographus peptide