Venom of Alexandrium tamarense culture
| Product ID | PTX-MTX-004 |
|---|---|
| Name | Alexandrium tamarense culture |
| Common Name(s) | saxitoxin reference, sodium channel blocker, marine toxin standard, analytical calibration toxin |
| Origin | Controlled algal bioreactor with ISO 9001 quality oversight |
| Purity | Certified 99.1% by qNMR |
| Form | 50 μg lyophilized standard with certified concentration |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price ($) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | 1200.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
The Venom Supplies saxitoxin standard originates from an Alexandrium tamarense culture harvested in a closed bioreactor. Purification employs activated charcoal adsorption and crystallization, yielding a highly purified toxin subsequently quantified using isotope dilution LC-MS/MS and quantitative NMR. Each vial carries a certified concentration with ±2% uncertainty.
Molecular targets
Saxitoxin occludes voltage-gated sodium channel pores, producing high-affinity blockade across NaV1.4, NaV1.5, and NaV1.7. Potency data report sub-nanomolar inhibition constants. The COA includes dose–response curves for NaV1.5 expressed in HEK293 cells and guidance on converting concentration to molar activity.
Research applications
- Marine toxin toxicology: Calibrate analytical assays monitoring paralytic shellfish toxins.
- Sodium channel safety testing: Benchmark cardiac NaV blockade in safety pharmacology programs.
- Analytical method validation: Validate LC-MS and ELISA detection platforms.
Navigate to Marine Toxins for complementary standards and the Cardiovascular Research application page for safety-focused insights. Blog reading: Best practices for handling and storing neurotoxins in the lab.
Format & handling
Reconstitute with 1 mL of 10 mM acetic acid for a 50 μg/mL stock. For analytical use, dilute with ultrapure water or mobile phase. Use low-binding polypropylene tubes to avoid adsorption.
Documentation
- COA: certified concentration, isotope dilution datasets, uncertainty budget, endotoxin (< 0.03 EU/μg).
- SDS: hazard classification, PPE, first aid.
Safety notes
Handle under BSL-2 conditions with calibrated pipettes. Keep antidote (activated charcoal) accessible per institutional policy. Neutralize residual solution with 10% bleach.
Related resources
- Complementary product: PTX-RCT-004 ω-Conotoxin MVIIA Recombinant
- Application synergy: Receptor Pharmacology
- Technical guidance: Support
Alexandrium tamarense culture