Venom of Theraphosa blondi
| Product ID | PTX-SPV-005 |
|---|---|
| Name | Theraphosa blondi |
| Common Name(s) | trpv1 toxin, trpa1 modulator, theraphosa venom, itch research toxin |
| Origin | Ethically maintained breeding colony with rainforest-mimetic habitat |
| Purity | >= 85% per fraction |
| Form | Three 75 μg lyophilized fractions |
| Packaging | In vacuum sealed glass vials, in secured parcel. |
| Packaging | Price ($) | Quantity | Buy Now |
|---|---|---|---|
| 100 mg | 750.00 |
| IUCN Status | Not Evaluated |
|---|---|
| CITES | See CITES Appendices |
| Local | Check Local Regulations |
Description & Applications
Description & origin
The Theraphosa TRP Modulator Set captures three chromatographically discrete fractions from Theraphosa blondi venom, each enriched for peptides influencing transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs). Venom Supplies employs orthogonal RP-HPLC and ion-exchange steps to segregate modulators by charge and hydrophobicity, delivering fractions with minimal cross-contamination.
Molecular targets
- Fraction A: Potentiates TRPV1 activation (EC₅₀ 22 nM) and enhances capsaicin-induced currents.
- Fraction B: Inhibits TRPA1 (IC₅₀ 18 nM) with high selectivity over TRPM8.
- Fraction C: Stabilizes ASIC1a closed state, dampening acid-induced currents (IC₅₀ 45 nM).
Calcium imaging curves and whole-cell patch-clamp traces are provided to support experimental planning.
Research applications
- Itch and pain signaling: Dissect neuronal pathways underlying sensory hypersensitivity.
- Respiratory neurobiology: Explore neurogenic bronchoconstriction mediated by TRP channels.
- Calcium imaging assays: Utilize defined modulators to validate high-content imaging workflows.
Reference the Spider Venoms category and align with Pain Research and Neuroscience application dossiers.
Format & handling
Reconstitute each fraction with 75 μL HEPES-buffered saline containing 0.1% BSA. Aliquot immediately into low-binding tubes. Avoid lyophilization cycles post-reconstitution.
Documentation
- COA: activity metrics, purity profiles, endotoxin (< 0.08 EU/μg), stability data.
- SDS: hazard classification, PPE, environmental precautions.
Safety notes
Wear protective sleeves to prevent dermal exposure. Clean surfaces with 0.5% sodium hypochlorite followed by 70% ethanol.
Related resources
- Linked product: PTX-MTX-001 ω-Conotoxin CVIF
- Application synergy: Receptor Pharmacology
- Procedural guidance: Support
Theraphosa blondi