Venom Supplies scorpion venoms emphasize peptide-rich fractions with direct relevance to ion channel and neuroimmune modulation. Collection partnerships with accredited breeders enable precise control over diet, photoperiod, and milking frequency, preserving the integrity of cysteine-stabilized α/β peptides. Each lot is desalted, lyophilized, and analytically confirmed using LC-MS/MS peptide mapping to profile major toxins, including α-toxins targeting voltage sensors and calcins modulating intracellular Ca²⁺…
Precision tools for potassium channel immunology
Pivotal immunomodulatory programs leverage Kv1.3-selective toxins such as margatoxin analogs to interrogate effector memory T cell function. Venom Supplies venoms from Centruroides and Leiurus species provide abundant Kv-active peptides characterized for IC₅₀ potency in patch-clamp assays. Supplementary data outline cross-reactivity against Kv1.2 and Kv1.6, guiding medicinal chemistry teams seeking narrow subtype selectivity.
Sodium channel subtype resolution for nociception
β-toxins prevalent in Tityus serrulatus venoms stabilize NaV1.7 and NaV1.8 activation, offering mechanistic insight into nociceptive firing and pain pathway sensitization. Investigators can reference included voltage-clamp traces highlighting gating shifts and recovery kinetics, enabling translational comparisons with patient-derived channel variants. Marine analgesic discovery programs frequently pair these venoms with Pain Research frameworks to benchmark novel blockers.
Data-rich documentation
Each batch ships with COA tables summarizing peptide content, endotoxin readings, and stability data derived from accelerated storage studies at 25 °C/60% RH. Safety guidance details recommended containment practices for neurotoxic peptides, aligning with institutional biosafety level 2 (BSL-2) expectations. Venom Supplies also offers custom fractionation to isolate single-component toxins supported by amino acid sequencing and disulfide bond mapping.
Explore related assets
- Representative listings such as PTX-SCV-003 Leiurus α-toxin concentrate and PTX-SCV-006 Centruroides Kv peptide panel deliver consistent toxin loads per vial.
- Deepen experimental planning through the Neuroscience application hub and cross-link to blog resources like How venom-derived toxins advance ion channel research.
- For immunology collaborations or autologous cell assays, consult the Support team for shipment documentation tailored to regulatory submissions.
Venom Supplies scorpion venoms combine ethically managed sourcing with peer-level documentation for precise, reproducible neuropharmacology workflows.