Venom of Bufo gargarizans

Product Details

Product ID	PTX-AMV-L3107
Name	Bufo gargarizans
Common Name(s)	asiatic toad, cinobufagin, bufalin, chan su
Origin	Captive-bred (Asia).
Purity	Whole Secretion
Form	Lyophilized powder
Packaging	In vacuum sealed glass vials, in secured parcel.

Packaging and Prices

Packaging	Price (€)	Quantity	Buy Now
100 mg	€140.00

Prices quoted in EUR (€) excl. VAT. Intra-EU express cold-chain delivery with zero customs delays from Valence, France. For bulk quantities, please Contact us.

Species Protection Status

IUCN Status	Not Evaluated
CITES	See CITES Appendices
Local	Check Local Regulations

Product Technical Documents

Safety Data Sheet (SDS) Available on request

Description & Applications

Product Description

The venom of Bufo gargarizans, commonly known as the Asiatic Toad, is a complex chemical cocktail secreted from the parotoid glands and skin. This secretion, historically known as Chan Su in Traditional Chinese Medicine (TCM), has been utilized for centuries for its potent therapeutic properties. Modern pharmacological research has identified it as a rich source of bufadienolides, a class of cardiotonic steroids that exhibit significant biological activity.

Key bioactive components include:

Cinobufagin: A potent cardiotonic steroid that has demonstrated strong anti-tumor efficacy in various cancer cell lines.
Bufalin: Known for its ability to induce apoptosis (programmed cell death) in leukemia and solid tumor cells, while also inhibiting cell proliferation.
Resibufogenin: Another major constituent with cardiotonic and anti-inflammatory properties.

Our Bufo gargarizans venom is collected from captive-bred specimens to ensure sustainability and consistency. The secretion is lyophilized (freeze-dried) to preserve the structural integrity of the bioactive peptides and steroids.

Research Applications

Oncology & Cancer Research:
- Investigation of bufadienolide-induced apoptosis pathways in human cancer cells (e.g., lung, liver, and prostate cancer).
- Study of the synergistic effects of toad venom components with conventional chemotherapy agents.
- Development of novel anti-cancer therapeutics targeting specific tumor markers.
Cardiovascular Pharmacology:
- Study of Na+/K+-ATPase inhibition, similar to the mechanism of digitalis, for potential applications in heart failure treatment.
- Analysis of the positive inotropic effects of bufadienolides on cardiac muscle.
Immunology & Inflammation:
- Evaluation of the anti-inflammatory and analgesic properties of the crude venom and its isolated fractions.
- Research into the modulation of immune responses by toad venom peptides.
Traditional Medicine Validation:
- Scientific validation of the pharmacological basis for the use of Chan Su in treating infections, pain, and swelling.