Venom tools for vascular and cardiac discovery

Harnessing venom diversity for cardiovascular insight

Cardiovascular biology spans coagulation, endothelial integrity, vascular tone, and cardiac excitability. Venom Supplies provides characterized venoms and recombinant toxins that modulate each facet. Working with hospital-based researchers, pharma teams, and CROs, we supply data-rich reagents that withstand regulatory scrutiny while delivering mechanistic clarity.

Coagulation and hemostasis modeling

Snake venoms remain indispensable for dissecting coagulation cascades:

• Bothrops metalloproteinase fraction (PTX-SNV-004) activates Factor X and cleaves fibrinogen, enabling assays that simulate disseminated intravascular coagulation.
• PLA2 catalytic domain (PTX-RCT-008) generates lysophospholipids implicated in platelet activation and inflammatory thrombosis.

Integrate these reagents in thromboelastography (TEG), chromogenic assays, or microfluidic coagulation platforms. Our COAs provide potency per milligram, ensuring assay normalization and reproducibility.

Vascular permeability and endothelial health

Venom enzymes and peptides modulate endothelial junctions and extracellular matrix integrity. Deploy the Bothrops fraction to model vascular leakage or use scorpion peptides to probe endothelial ion channel contributions to barrier function. Pair toxins with trans-endothelial electrical resistance (TEER) measurements, confocal imaging of tight junction proteins, or permeability assays using fluorescent dextrans.

Cardiac electrophysiology and arrhythmia screening

Voltage-gated sodium and calcium channel toxins offer precise tools for cardiac safety pharmacology:

• Saxitoxin certified reference (PTX-MTX-004) blocks NaV1.5, establishing positive controls for action potential measurements in human iPSC cardiomyocytes.
• Crotalus neurotoxin complex (PTX-SNV-001) informs neuromuscular blocking effects relevant to diaphragmatic function.
• ω-Conotoxin CVIF (PTX-MTX-001) benchmarks CaV2.x modulation pertinent to vascular tone and sympathetic outflow.

Incorporate these toxins into multi-electrode array recordings, patch clamp assays, or optical mapping of voltage-sensitive dyes. Documentation includes solvent compatibility and recommended concentrations for isolating specific current components.

Integration with translational pipelines

1. Target identification: Use the Toxins by Target catalog to align toxins with NaV, Kv, or CaV isoforms relevant to cardiac and vascular tissues.
2. Assay selection: Choose between in vitro plate-based assays, organ-on-chip systems, or ex vivo vessel preparations, guided by potency and stability data.
3. Data harmonization: Record toxin lot numbers, potency confirmation, and storage conditions to comply with GLP, ISO 13485, or internal QA frameworks.
4. Regulatory readiness: Venom Supplies documentation supports submissions to institutional review boards, preclinical safety packages, and collaborative grants.

Safety and logistics

Venoms and toxins require controlled handling. Our Ordering & Shipping guidance outlines cold-chain logistics, customs documents, and hazard classifications. SDS files enumerate PPE, first aid, and neutralization procedures. All products meet endotoxin limits aligned with in vitro diagnostic and preclinical expectations.

Related resources

• Cross-application: Ion Channel Research for electrophysiology strategies and Pain Research for shared target considerations.
• Blog reading: Best practices for handling and storing neurotoxins in the lab.
• Support: Contact the Support team for custom concentration formats, buffer optimization, or documentation packages tailored to regulatory filings.

Through rigorous analytics, ethical sourcing, and consultative support, Venom Supplies equips cardiovascular researchers with precision tools to interrogate coagulation, endothelial dynamics, and cardiac electrophysiology.